Ibutamoren (MK-677) is a growth hormone secretagogue that may improve longevity. Research is being done to detect Alzheimer’s disease, frailty in the elderly and growth hormone deficiency.
Athletes also use MK-677 to gain a competitive advantage in sports. MK-677 binds to the ghrelin receptor, mimicking the effects of ghrelin. These effects included increased appetite, muscle mass, bone mineral density, angiogenesis, VEGF expression, protection of the heart, and modulation of glucose and energy homeostasis.
Ibutamoren is frequently discussed in online forums for its anabolic muscle-building properties. It is available without a prescription and is used by those who want to increase their growth hormone levels. However, clinical studies of this compound are relatively few. In the text below, we will highlight what is known about ibutamoren so far.
Ibutamoren (MK-677) promotes growth hormone (GH) secretion and increases insulin-like growth factor 1 (IGF-1).
It increases growth hormone levels, mimicking the action of the ghrelin (R) hormone and binding to one of the ghrelin receptors (GHSR) in the brain. GHSR will stimulate the release of growth hormone from the brain.
One great thing about ibutamoren is that it increases growth hormone levels with little to no increase in other hormones, such as cortisol. Cortisol suppresses the immune system, reduces wound healing, and affects learning and memory, and it is generally not good to have this hormone elevated.
BENEFITS
Ibutamoren (MK-677) was originally formulated to treat health problems such as osteoporosis, obesity, and muscle wasting, but has been found to promote an increase in lean body mass as well as an increase in fat oxidation (loss of fat).
→ Increased muscle gains (lean mass).
→ Tighten sagging skin.
→ Healing old wounds.
→ Healing of bones, tendons and ligaments.
→ Inhibits somatostatin receptor signaling.
→ Slows down the activity of somastostatin in the system.
→ Amplifies and increases the overall production and release of (GHRH)
→ Improves somatotropin signaling in growth hormone releasing hormones (GHRH)
This is all just information.
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